对QuickVue的评估，一种用于检测幽门螺杆菌血清抗体的快速酶免疫测定试验。

Evaluation of QuickVue, a rapid enzyme immunoassay test for the detection of serum antibodies to Helicobacter pylori.

作者信息

Westblom T U, Lagging L M, Midkiff B R, Czinn S J

机构信息

Division of Infectious Diseases and Immunology, St. Louis University School of Medicine, MO 63104.

出版信息

Diagn Microbiol Infect Dis. 1993 May-Jun;16(4):317-20. doi: 10.1016/0732-8893(93)90082-i.

DOI:10.1016/0732-8893(93)90082-i

PMID:8495587

Abstract

QuickVue is an enzyme immunoassay test for qualitative detection of serum immunoglobulin-G antibodies to Helicobacter pylori. We evaluated its ability to predict infection by H. pylori in 100 adult and 49 pediatric patients referred for gastric endoscopy. A patient was defined as infected with H. pylori if either culture or histology was positive. Of the 100 adult patients, 64 had H. pylori infection and QuickVue correctly identified 59 of the 64. Of 36 H. pylori-negative patients, 20 were correctly identified as negative by the test. In this sample of patients, QuickVue had a sensitivity of 92% and a specificity of 56%. In the 49 pediatric patients, QuickVue correctly identified nine of 11 infected cases and 34 of 38 noninfected patients. In this group, the sensitivity was 82% and the specificity was 89%. Overall the test had a sensitivity of 91% and a specificity of 73%. The positive predictive value was 77% and the negative predictive value was 89%.

摘要

QuickVue是一种酶免疫测定试验，用于定性检测血清中抗幽门螺杆菌的免疫球蛋白G抗体。我们评估了其在100名成年和49名儿科胃内镜检查患者中预测幽门螺杆菌感染的能力。如果培养或组织学检查呈阳性，则患者被定义为感染幽门螺杆菌。在100名成年患者中，64人感染了幽门螺杆菌，QuickVue正确识别出了64人中的59人。在36名幽门螺杆菌阴性患者中，20人被该检测正确识别为阴性。在这个患者样本中，QuickVue的敏感性为92%，特异性为56%。在49名儿科患者中，QuickVue正确识别出了11例感染病例中的9例和38例未感染患者中的34例。在该组中，敏感性为82%，特异性为89%。总体而言，该检测的敏感性为91%，特异性为73%。阳性预测值为77%，阴性预测值为89%。