Balu J N
Clin Exp Immunol. 1977 Feb;27(2):340-7.
The circulatory patterns in three lymphoid tissues were compared macro- and microscopically. Indian ink or a viscous silicone rubber compound were used as contrast materials and serial 75 micronm sections examined. The findings were checked with the benzidine stain for red blood corpuscles in uninjected tissues. Thymic lobules showed a "through circulation"--capillaries penetrating the cortex from within outwards and draining into surface veins, comparable with the circulation in liver lobules. By contrast, lymph nodes and Peyer's patches showed a looped capillary distribution. The outer thymic cortex and primary follicles in lymph nodes contained the maximum capillary density, correlating with the highest mitotic index of thymocytes and lymphocytes in the respective tissues. The lowest vascular density in the thymus was in the medulla, particularly in Hassall's corpuscles, in secondary follicles of lympho nodes and Peyer's patches, which correlates with the storage capacity of antigens and antibodies at those sites. Postcapillary venules in lymph nodes and Peyer's patches showed a characteristic pattern with Indian ink. These venules were absent from the thymus.
对三种淋巴组织的循环模式进行了大体和显微镜下的比较。使用印度墨水或粘性硅橡胶化合物作为对比材料，并检查了连续的75微米切片。在未注射的组织中，用联苯胺染色检查红细胞，以验证研究结果。胸腺小叶呈现“贯穿循环”——毛细血管从内部向外穿透皮质，然后排入表面静脉，这与肝小叶中的循环类似。相比之下，淋巴结和派尔集合淋巴结呈现出环状毛细血管分布。胸腺的外层皮质和淋巴结中的初级滤泡毛细血管密度最高，这与相应组织中胸腺细胞和淋巴细胞的最高有丝分裂指数相关。胸腺中血管密度最低的部位是髓质，特别是哈氏小体，以及淋巴结和派尔集合淋巴结的次级滤泡，这与这些部位抗原和抗体的储存能力相关。用印度墨水观察时，淋巴结和派尔集合淋巴结中的毛细血管后微静脉呈现出特征性模式。胸腺中没有这些微静脉。
