Bhalla D K, Murakami T, Owen R L
Gastroenterology. 1981 Sep;81(3):481-91.
Peyer's patch microvasculature carries recirculating lymphoid cells into lymphoid follicles and supports vigorous metabolic demands of crypts and replicating germinal centers. Scanning electron microscopy of methyl methacrylate casts of blood vessels in rat intestinal Peyer's patches revealed that ascending arterioles pierce follicles and feed to a subepithelial capillary network beneath the follicle surface. These capillaries interconnect with baskets of capillaries beneath adjacent crypts and flow into postcapillary venules in thymus-dependent areas around the follicle perimeters. This pattern is a modification of the fountain pattern in villi and reflects the secondary development of germinal centers of B lymphocytes between central ascending arterioles and peripheral postcapillary venules. Sections of glycol methacrylate-embedded follicles injected with India ink revealed multiple fine capillaries in germinal centers not detected by previous techniques. Capillary flow from follicle apex to adjacent crypts provides a route for feedback control of replenishment of the specialized antigen-trapping epithelium covering follicles, and it is an opportunity for absorbed materials and cellular products beneath the epithelium to modify migration of lymphocytes out of postcapillary venules into follicles.
派尔集合淋巴结的微脉管系统将再循环的淋巴细胞输送到淋巴滤泡中，并支持隐窝和增殖生发中心的旺盛代谢需求。对大鼠肠道派尔集合淋巴结血管的甲基丙烯酸甲酯铸型进行扫描电子显微镜观察发现，上升的小动脉穿透滤泡，并为滤泡表面下方的上皮下毛细血管网络供血。这些毛细血管与相邻隐窝下方的毛细血管篮相互连接，并流入滤泡周边胸腺依赖区的毛细血管后微静脉。这种模式是绒毛中喷泉模式的一种变体，反映了B淋巴细胞生发中心在中央上升小动脉和外周毛细血管后微静脉之间的二次发育。注射印度墨水的乙二醇甲基丙烯酸酯包埋滤泡切片显示，生发中心有多个先前技术未检测到的细毛细血管。从滤泡顶端到相邻隐窝的毛细血管流动为覆盖滤泡的特殊抗原捕获上皮的补充反馈控制提供了一条途径，并且这是上皮下方吸收的物质和细胞产物改变淋巴细胞从毛细血管后微静脉迁移到滤泡中的一个机会。
