人类免疫缺陷病毒1型gp120的V1环中的单个氨基酸取代会改变细胞嗜性。
A single amino acid substitution in the V1 loop of human immunodeficiency virus type 1 gp120 alters cellular tropism.
作者信息
Boyd M T, Simpson G R, Cann A J, Johnson M A, Weiss R A
机构信息
Chester Beatty Laboratories, Institute of Cancer Research, London, United Kingdom.
出版信息
J Virol. 1993 Jun;67(6):3649-52. doi: 10.1128/JVI.67.6.3649-3652.1993.
Abstract
Specific point mutations which affect viral tropism have been identified in both the V3 loop and in the CD4-binding region of the human immunodeficiency virus type 1 surface glycoprotein gp120. Here we report that a single point mutation in the first variable region (V1) of human immunodeficiency virus type 1 strain JRCSF is responsible for a change in viral tropism.
摘要
在人类免疫缺陷病毒1型表面糖蛋白gp120的V3环和CD4结合区域均已鉴定出影响病毒嗜性的特定点突变。在此我们报告，人类免疫缺陷病毒1型JRCSF毒株第一个可变区（V1）中的单个点突变导致了病毒嗜性的改变。
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