Henry R E, Wegmann J A, Hartle J E, Christopher G W
United States Air Force Medical Center Scott, Scott Air Force Base, Illinois 62225-5300.
Ann Allergy. 1993 May;70(5):386-8.
A 65-year-old woman with the acquired immunodeficiency syndrome (AIDS) complicated by recurrent mucocutaneous herpes simplex virus (HSV) infection developed angioedema on the initiation of her second course of oral acyclovir therapy. Oral rechallenge in hospital three days later confirmed acyclovir hypersensitivity. Vidarabine and foscarnet therapies were abandoned after treatment failure and unacceptable toxicity. Acyclovir desensitization was accomplished using a protocol derived from oral penicillin desensitization regimens. Mucocutaneous HSV infection responded to intravenous acyclovir followed by chronic oral suppression without recurrences of HSV or hypersensitivity. This report is an example of acyclovir hypersensitivity and successful oral desensitization.
一名65岁患有获得性免疫缺陷综合征（艾滋病）并伴有复发性黏膜皮肤单纯疱疹病毒（HSV）感染的女性，在开始第二疗程口服阿昔洛韦治疗时出现血管性水肿。三天后在医院进行口服激发试验证实了阿昔洛韦超敏反应。在治疗失败和出现无法接受的毒性后，放弃了阿糖腺苷和膦甲酸钠治疗。使用源自口服青霉素脱敏方案的方案完成了阿昔洛韦脱敏。黏膜皮肤HSV感染对静脉注射阿昔洛韦有反应，随后进行长期口服抑制，HSV未复发且无超敏反应。本报告是阿昔洛韦超敏反应及成功口服脱敏的一个实例。
