Konishi H, Nakajima T, Sano I
J Biochem. 1977 Feb;81(2):355-60. doi: 10.1093/oxfordjournals.jbchem.a131466.
The metabolism of putrescine in rat brain was studied systematically by the intraventricular injection of radioactive diamine. Putrescine injected into the brain was metabolized mainly to polyamines, spermidine, and spermine. A small portion of the radioactivity of putrescine was incorporated into gamma-glutamylputrescine, putreanine, gamma-aminobutyric acid, and homocarnosine. Comparison of the specific radioactivities of gamma-aminobutyric acid and homocarnosine after the injection of radioactive putrescine with those after the injection of radioactive glutamic acid indicated that there may be a metabolic pool of gamma-aminobutyric acid (putrescine-gamma-aminobutyric acid system) which is different from the glutamic acid-gamma-aminobutyric acid system and which is effectively used for synthesis of the dipeptide.
通过脑室内注射放射性二胺，系统研究了大鼠脑中腐胺的代谢。注入脑中的腐胺主要代谢为多胺、亚精胺和精胺。腐胺的一小部分放射性被整合到γ-谷氨酰腐胺、腐胺酸、γ-氨基丁酸和高肌肽中。注射放射性腐胺后γ-氨基丁酸和高肌肽的比放射性与注射放射性谷氨酸后的比放射性比较表明，可能存在一个与谷氨酸-γ-氨基丁酸系统不同的γ-氨基丁酸代谢池（腐胺-γ-氨基丁酸系统），该代谢池可有效用于二肽的合成。
