Maharaj B, Khedun S M, Gregory M A, Naicker T
Department of Experimental Pharmacology, Medical School, University of Natal, Durban, South Africa.
Int J Exp Pathol. 1993 Apr;74(2):145-50.
Specimens from the left ventricular myocardium of 10 rats that had been exposed to subcutaneously administered hexane for 30 days were morphometrically and morphologically examined. Other than the presence of occasional necrotic fibres in hexane-treated animals, there was little difference in the histological appearance of myofibres in control or experimental specimens. There was a slight reduction in the average diameter of cardiac myofibres after exposure to hexane. Pathological ultrastructural changes of the myofibres were noted in the experimental and not in the control groups. Mitochondrial oedema and necrosis and myofilament disorganization and dissolution were significant changes noted in the experimental group. These pathological changes suggest that hexane, a constituent of glue and benzine, is cardiotoxic.
对10只皮下注射己烷30天的大鼠的左心室心肌标本进行了形态计量学和形态学检查。除了在己烷处理的动物中偶尔出现坏死纤维外，对照或实验标本中肌纤维的组织学外观几乎没有差异。接触己烷后心肌纤维的平均直径略有减小。在实验组中观察到了肌纤维的病理性超微结构变化，而对照组未观察到。实验组中显著的变化包括线粒体水肿和坏死以及肌丝紊乱和溶解。这些病理变化表明，胶水和汽油的成分己烷具有心脏毒性。
