Bartlett J G, Miao P V, Gorbach S L
J Infect Dis. 1977 Mar;135 Suppl:S80-5. doi: 10.1093/infdis/135.supplement.s80.
Clindamycin and gentamicin were used in combination to treat 107 patients empirically for suspected aerobic-anaerobic sepsis. All patients were seriously ill and required initiation of treatment before results of cultures could be obtained. Infections included intraabdominal sepsis, hospital-acquired aspiration pneumonia, and soft tissue infections. Exudate cultured from 65 patients showed that the prediction of a mixed aerobic-anaerobic flora was correct in 46 patients (71%). Isolates from exudate included Escherichia coli, Bacteroides fragilis, clostridia, peptostreptococci, Proteus species, Klebsiella species, and Staphylococcus aureus. In 29 patients with bacteremia, the most frequent blood culture isolate was B. fragilis. Analysis of response to treatment showed that 92 patients were cured, five could not be evaluated adequately, and 10 failed to respond to therapy. Therapeutic failure primarily resulted from overwhelming sepsis, despite susceptibility of the pathogens to prescribed antibiotics.
克林霉素和庆大霉素联合使用，对107例疑似需氧-厌氧败血症患者进行经验性治疗。所有患者病情严重，在获得培养结果之前就需要开始治疗。感染包括腹腔内败血症、医院获得性吸入性肺炎和软组织感染。对65例患者的渗出液进行培养，结果显示，46例患者（71%）的需氧-厌氧混合菌群预测正确。渗出液分离出的菌株包括大肠杆菌、脆弱拟杆菌、梭菌、消化链球菌、变形杆菌属、克雷伯菌属和金黄色葡萄球菌。在29例菌血症患者中，血培养最常见的分离菌株是脆弱拟杆菌。治疗反应分析显示，92例患者治愈，5例无法进行充分评估，10例治疗无效。尽管病原体对规定使用的抗生素敏感，但治疗失败主要是由于败血症病情严重所致。
