鲨烯抑制素1对鲨烯合酶的竞争性抑制作用。 - Suppr

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超能文献

Competitive inhibition of squalene synthetase by squalestatin 1.

作者信息

Hasumi K, Tachikawa K, Sakai K, Murakawa S, Yoshikawa N, Kumazawa S, Endo A

机构信息

Department of Applied Biological Science, Tokyo Noko University, Japan.

出版信息

J Antibiot (Tokyo). 1993 Apr;46(4):689-91. doi: 10.7164/antibiotics.46.689.

DOI:10.7164/antibiotics.46.689

PMID:8501015

Abstract

摘要

相似文献

Competitive inhibition of squalene synthetase by squalestatin 1.鲨烯抑制素1对鲨烯合酶的竞争性抑制作用。

J Antibiot (Tokyo). 1993 Apr;46(4):689-91. doi: 10.7164/antibiotics.46.689.

Production of additional squalestatin analogues by directed biosynthesis.通过定向生物合成生产额外的角鲨他汀类似物。

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The squalestatins, novel inhibitors of squalene synthase produced by a species of Phoma. II. Structure elucidation.角鲨菌素，一种茎点霉属菌株产生的新型鲨烯合酶抑制剂。II. 结构解析。

J Antibiot (Tokyo). 1992 May;45(5):648-58. doi: 10.7164/antibiotics.45.648.

Zaragozic acids D and D2: potent inhibitors of squalene synthase and of Ras farnesyl-protein transferase.扎拉戈昔酸D和D2：鲨烯合酶及Ras法尼基蛋白转移酶的强效抑制剂。

J Nat Prod. 1993 Nov;56(11):1923-9. doi: 10.1021/np50101a009.

The squalestatins, novel inhibitors of squalene synthase produced by a species of Phoma. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activity.角鲨烯合酶的新型抑制剂——茎点霉属真菌产生的角鲨他汀。I. 分类学、发酵、分离、理化性质及生物活性

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Squalestatin 1, a potent inhibitor of squalene synthase, which lowers serum cholesterol in vivo.鲨烯抑素1，一种强效的鲨烯合酶抑制剂，可在体内降低血清胆固醇。

J Biol Chem. 1992 Jun 15;267(17):11705-8.

Comparative study of the inhibition of rat and tobacco squalene synthase by squalestatins.鲨烯抑制素对大鼠和烟草鲨烯合酶抑制作用的比较研究

Phytochemistry. 1995 Mar;38(5):1137-41. doi: 10.1016/0031-9422(94)00798-x.

Zaragozic acids: a family of fungal metabolites that are picomolar competitive inhibitors of squalene synthase.扎拉戈昔酸：一类真菌代谢产物，是角鲨烯合酶的皮摩尔级竞争性抑制剂。

Proc Natl Acad Sci U S A. 1993 Jan 1;90(1):80-4. doi: 10.1073/pnas.90.1.80.

Selective inhibition of cholesterol biosynthesis in brain cells by squalestatin 1.角鲨他汀1对脑细胞中胆固醇生物合成的选择性抑制作用。

J Neurochem. 1995 Sep;65(3):1365-73. doi: 10.1046/j.1471-4159.1995.65031365.x.

Inhibition of mammalian squalene synthetase activity by zaragozic acid A is a result of competitive inhibition followed by mechanism-based irreversible inactivation.扎戈齐克酸A对哺乳动物鲨烯合酶活性的抑制作用是竞争性抑制随后基于机制的不可逆失活的结果。

J Biol Chem. 1995 Apr 21;270(16):9083-96. doi: 10.1074/jbc.270.16.9083.

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