Holmes E C, Zhang L Q, Simmonds P, Rogers A S, Brown A J
Centre for HIV Research, University of Edinburgh, United Kingdom.
J Infect Dis. 1993 Jun;167(6):1411-4. doi: 10.1093/infdis/167.6.1411.
Recall of patients who had been treated by a human immunodeficiency virus (HIV)-infected surgeon uncovered 1 previously unknown HIV-seropositive person. Nucleotide sequencing of the gag gene and maximum likelihood phylogenetic analysis were used to investigate the relationships among sequences from the surgeon, the patient, and an anonymous blood donor from whom the patient had received blood products. The likelihoods of all possible pathways of transmission linking these persons were estimated. On these data, transmission from the surgeon to the patient was significantly less likely than from the blood donor to the patient. It is concluded that none of the recalled patients were infected by the surgeon.
对曾由一名感染人类免疫缺陷病毒（HIV）的外科医生治疗过的患者进行回顾，发现了1名此前未知的HIV血清反应阳性者。使用gag基因的核苷酸测序和最大似然系统发育分析来研究来自外科医生、该患者以及该患者曾接受血液制品的一名匿名献血者的序列之间的关系。估计了将这些人联系起来的所有可能传播途径的可能性。基于这些数据，外科医生传播给患者的可能性显著低于献血者传播给患者的可能性。得出的结论是，所有被回顾的患者均未被外科医生感染。
