Holmes E C, Zhang L Q, Robertson P, Cleland A, Harvey E, Simmonds P, Leigh Brown A J
Centre for HIV Research, Medical School, University of Edinburgh, Scotland.
J Infect Dis. 1995 Jan;171(1):45-53. doi: 10.1093/infdis/171.1.45.
Human immunodeficiency virus (HIV) type 1 sequences obtained from HIV-infected persons in different risk groups in Edinburgh were studied to determine the number and origin of virus variants and patterns of virus transmission. Phylogenetic analysis revealed that 12 of 14 hemophiliac patients who had been exposed to a single common batch of factor VIII had closely related gag gene sequences. Sequences from intravenous drug users and patients infected through heterosexual contact formed another distinct group, and 2 other hemophiliacs formed a third group. However, epidemiologic relationships inferred from analysis of the V3 region of the env gene were less conclusive, especially when the V3 loop was taken in isolation. This appears to be due to the length of time since infection and the action of selection, which has favored the independent appearance of similar V3 loop variants.
对从爱丁堡不同风险群体的HIV感染者中获得的1型人类免疫缺陷病毒（HIV）序列进行了研究，以确定病毒变体的数量、来源及病毒传播模式。系统发育分析显示，14名血友病患者中有12名曾接触过同一批次的凝血因子VIII，他们的gag基因序列密切相关。静脉吸毒者和通过异性接触感染的患者的序列形成了另一个不同的组，另外2名血友病患者形成了第三组。然而，从env基因V3区域分析推断出的流行病学关系不太明确，尤其是单独分析V3环时。这似乎是由于感染后的时间长度以及选择作用，后者有利于相似V3环变体的独立出现。
