Suzuki W A, Zola-Morgan S, Squire L R, Amaral D G
Group in Neurosciences, University of California at San Diego, La Jolla 92093.
J Neurosci. 1993 Jun;13(6):2430-51. doi: 10.1523/JNEUROSCI.13-06-02430.1993.
Compared to normal animals, monkeys with bilateral lesions of the perirhinal and parahippocampal cortices (PRPH lesion) were impaired on both a visual and a tactual version of the delayed nonmatching to sample task. In addition, the memory deficit was long-lasting, as indicated by the finding of a significant deficit when the visual version of the delayed nonmatching to sample task was readministered approximately 2 years after surgery. Animals with PRPH lesions performed normally on discrimination tasks in the visual and tactual modalities. Multimodal and long-lasting memory impairments are defining characteristics of human medial temporal lobe amnesia. Accordingly, these results demonstrate important parallels between the memory deficit associated with PRPH lesions and human medial temporal lobe amnesia. These data, taken together with previous findings, suggest that the perirhinal and parahippocampal cortices play an important role in memory function and that these cortical areas are critical components of the medial temporal lobe memory system.
与正常动物相比，双侧嗅周皮质和海马旁皮质损伤（PRPH损伤）的猴子在视觉和触觉版本的延迟非匹配样本任务中均表现受损。此外，记忆缺陷是持久的，这一点通过在手术后约2年重新进行视觉版本的延迟非匹配样本任务时发现显著缺陷得以表明。PRPH损伤的动物在视觉和触觉模式的辨别任务中表现正常。多模式和持久的记忆损伤是人类内侧颞叶失忆症的典型特征。因此，这些结果证明了与PRPH损伤相关的记忆缺陷与人类内侧颞叶失忆症之间存在重要的相似之处。这些数据与先前的研究结果相结合，表明嗅周皮质和海马旁皮质在记忆功能中发挥着重要作用，并且这些皮质区域是内侧颞叶记忆系统的关键组成部分。
