Tyler J W, Welles E G, Sorjonen D C, Spano J S, Gaslin J T, Spears H
Department of Large Animal Surgery and Medicine, College of Veterinary Medicine, Auburn University, Alabama 36849.
J Vet Intern Med. 1993 Mar-Apr;7(2):91-4. doi: 10.1111/j.1939-1676.1993.tb03175.x.
This study examined the safety of intravenous hypertonic saline in cattle with experimental gram-negative endotoxemia. Cerebrospinal fluid (CSF) composition was examined in five control cows and eight treated cows 24 hours after the intramammary infusion of 1 mg of endotoxin. Four of the endotoxin challenged cows were treated intravenously with isotonic (0.9%) sodium chloride and four cows were treated intravenously with hypertonic (7.5%) sodium chloride. Decreased CSF osmolality, and sodium and alpha globulin concentrations and increased CSF concentrations of beta globulin were observed in both endotoxin-challenged saline-treated groups. No CSF compositional differences were observed between endotoxin-challenged cows receiving isotonic or hypertonic saline. Although no cytologic or biochemical evidence of salt poisoning was observed in cows receiving hypertonic saline, significant changes were observed in the CSF composition of both endotoxin-infused saline-treated groups.
本研究检测了静脉输注高渗盐水对实验性革兰氏阴性内毒素血症牛的安全性。在向乳房内注入1毫克内毒素24小时后，对5头对照奶牛和8头接受治疗的奶牛的脑脊液（CSF）成分进行了检测。4头受到内毒素攻击的奶牛静脉注射等渗（0.9%）氯化钠，4头奶牛静脉注射高渗（7.5%）氯化钠。在两个内毒素攻击盐水治疗组中均观察到脑脊液渗透压、钠和α球蛋白浓度降低，以及脑脊液β球蛋白浓度升高。接受等渗或高渗盐水的内毒素攻击奶牛之间未观察到脑脊液成分差异。虽然在接受高渗盐水的奶牛中未观察到盐中毒的细胞学或生化证据，但在内毒素注入盐水治疗组的脑脊液成分中均观察到显著变化。
