Turner J W, Hawes D R, Williams R D
Department of Urology, University of Iowa Hospitals and Clinics, Iowa City.
J Urol. 1993 Jun;149(6):1482-4. doi: 10.1016/s0022-5347(17)36422-4.
The diagnosis of prostate cancer metastatic to bone currently is made with plain x-rays, radionuclide bone scans, and acid and alkaline phosphatases. We used magnetic resonance imaging (MRI) in 18 patients with known prostate cancer to resolve conflicting evidence of metastases found on bone scans, plain films and serum enzyme determinations. Of 8 bone scans interpreted as positive MRI was read as negative for metastatic disease in 2. Of 5 negative bone scans 1 MRI study was interpreted as positive. All 5 equivocal bone scans demonstrated no osseous lesions on MRI. In addition, in 6 patients with evidence of bone metastases the serial MRI scans following hormonal therapy demonstrated radiographic and clinical improvement. We conclude that MRI is helpful in the diagnosis of metastatic prostate cancer when other radiographic examinations are enigmatic and that MRI can be used to determine the response to hormonal treatment.
目前，前列腺癌骨转移的诊断依靠普通X线、放射性核素骨扫描以及酸性和碱性磷酸酶检查。我们对18例已知患有前列腺癌的患者进行了磁共振成像（MRI）检查，以解决在骨扫描、平片和血清酶测定中发现的关于转移的相互矛盾的证据。在8例骨扫描显示为阳性的病例中，MRI显示有2例无转移性疾病。在5例骨扫描为阴性的病例中，有1例MRI检查显示为阳性。所有5例可疑的骨扫描在MRI上均未显示骨病变。此外，在6例有骨转移证据的患者中，激素治疗后的系列MRI扫描显示影像学和临床症状均有改善。我们得出结论，当其他影像学检查结果不明确时，MRI有助于前列腺癌转移的诊断，并且MRI可用于确定激素治疗的反应。
