Khin N A, Hoffman S A
Department of Microbiology, Arizona State University, Tempe 85287-2701.
J Neuroimmunol. 1993 May;44(2):137-48. doi: 10.1016/0165-5728(93)90035-w.
To determine the role of auto-antibodies in the pathogenesis of neuropsychiatric manifestations of systemic lupus erythematosus (NP-SLE), it will be necessary to characterize the diversity of auto-antibodies that exist. This can be done by producing a library of monoclonal, brain-reactive auto-antibodies. From such a library the antigens to which the antibodies bind, and whether there are any interesting relations between these antigens, can be determined. Behavioral effects can also be investigated. Toward these ends, brain-reactive monoclonal auto-antibodies (BRMA) were produced. The production and characterization of two monoclonal antibodies is presented in this study.
为了确定自身抗体在系统性红斑狼疮神经精神表现（NP-SLE）发病机制中的作用，有必要对现有的自身抗体多样性进行表征。这可以通过构建一个单克隆脑反应性自身抗体文库来实现。从这样一个文库中，可以确定抗体所结合的抗原，以及这些抗原之间是否存在任何有趣的关系。还可以研究行为效应。为此，制备了脑反应性单克隆自身抗体（BRMA）。本研究展示了两种单克隆抗体的制备和表征。
