Ganjoo R K, Malpas J S, Plowman P N
Imperial Cancer Research Fund Department of Medical Oncology, St Bartholomew's Hospital, West Smithfield, London, UK.
Postgrad Med J. 1993 Feb;69(808):153-4. doi: 10.1136/pgmj.69.808.153.
A 40 year old woman presented with a spinal epidural tumour, which on histology was shown to be a plasmacytoma. At that time she had no evidence of multiple myeloma. Ten months later, she developed a second isolated plasmacytoma in the spleen, for which she underwent splenectomy. Two years after her initial presentation she had another recurrence in the liver, followed by a full-blown picture of multiple myeloma. The myeloma was progressive and resistant to all forms of chemotherapy. She finally died of a massive gastrointestinal haemorrhage. The clinical features, natural evolution and management of solitary plasmacytomas are discussed.
一名40岁女性因脊髓硬膜外肿瘤就诊，组织学检查显示为浆细胞瘤。当时她没有多发性骨髓瘤的证据。10个月后，她脾脏出现了第二个孤立性浆细胞瘤，并接受了脾切除术。初次就诊两年后，她肝脏再次复发，随后出现了典型的多发性骨髓瘤症状。骨髓瘤呈进行性发展，对所有形式的化疗均耐药。她最终死于大量胃肠道出血。本文讨论了孤立性浆细胞瘤的临床特征、自然病程及治疗方法。
