Sullivan R M, Parker B A, Szechtman H
Department of Biomedical Sciences, McMaster University, Hamilton, Ont., Canada.
Brain Res. 1993 Apr 23;609(1-2):347-50. doi: 10.1016/0006-8993(93)90895-t.
The present study examines the effects of sectioning the corpus callosum on the expression of asymmetric behaviors induced by a unilateral 6-hydroxydopamine (6-OHDA) lesion of the substantial nigra. Severing the corpus callosum eliminated the asymmetry in spontaneous investigation of edges in an open-field, without affecting total time of investigation. In contrast, callosotomy reduced the magnitude of externally cued turning, but failed to affect the directional distribution of responding. Moreover, it reduced the magnitude of apomorphine- but not amphetamine-induced turning. It is suggested that transcallosal communication is required for those behavioral asymmetries induced by a unilateral dopamine lesion which depend on head, rather than whole body movements.
本研究考察了切断胼胝体对由单侧6-羟基多巴胺（6-OHDA）损伤黑质所诱导的不对称行为表达的影响。切断胼胝体消除了在旷场中对边缘进行自发探究时的不对称性，但不影响总的探究时间。相比之下，胼胝体切开术降低了外部线索诱导的转向幅度，但未影响反应的方向分布。此外，它降低了阿扑吗啡诱导的转向幅度，但未影响安非他明诱导的转向幅度。研究表明，对于由单侧多巴胺损伤所诱导的、依赖头部而非全身运动的那些行为不对称性而言，胼胝体间的交流是必需的。
