Krupp L B, Jandorf L, Coyle P K, Mendelson W B
Dept of Neurology, State University of New York, Stony Brook 11794-8121.
J Psychosom Res. 1993 May;37(4):325-31. doi: 10.1016/0022-3999(93)90134-2.
Sleep and fatigue characteristics were evaluated in 72 patients who met major criteria for the chronic fatigue syndrome (CFS), 57 multiple sclerosis (MS) patients preselected for fatigue complaints, and 40 healthy controls. Using previously validated rating scales, CFS patients had significant elevations in fatigue and sleep disturbance compared to the MS and healthy control groups. To confirm these subjective measures, polysomnography was carried out in a subgroup of CFS patients who included sleep disturbance as one of their symptoms on initial clinical interview. In 10 of 16 (62.5%) polysomnography revealed clinically significant and potentially treatable sleep abnormalities. Their sleep disorders included periodic movement disorder (4), excessive daytime sleepiness (3), apnea (2), and narcolepsy (1). We conclude that subjective sleep disturbance is common in CFS and some CFS patients may have objective sleep disorders.
对72名符合慢性疲劳综合征（CFS）主要标准的患者、57名因疲劳症状而预先挑选出的多发性硬化症（MS）患者以及40名健康对照者的睡眠和疲劳特征进行了评估。使用先前经过验证的评分量表，与MS组和健康对照组相比，CFS患者的疲劳和睡眠障碍显著升高。为了证实这些主观测量结果，对一组CFS患者进行了多导睡眠图检查，这些患者在初次临床访谈时将睡眠障碍作为其症状之一。在16名患者中的10名（62.5%），多导睡眠图显示出具有临床意义且可能可治疗的睡眠异常。他们的睡眠障碍包括周期性肢体运动障碍（4例）、日间过度嗜睡（3例）、呼吸暂停（2例）和发作性睡病（1例）。我们得出结论，主观睡眠障碍在CFS中很常见，并且一些CFS患者可能存在客观睡眠障碍。
