Buchwald D, Pascualy R, Bombardier C, Kith P
Department of Medicine, University of Washington, Seattle.
Clin Infect Dis. 1994 Jan;18 Suppl 1:S68-72. doi: 10.1093/clinids/18.supplement_1.s68.
This prospective, cohort study examined the prevalence of sleep disorders among highly selected patients with chronic fatigue. On the basis of responses suggestive of sleep pathology on a screening questionnaire, 59 patients from a university-based clinic for chronic fatigue who had undergone a medical and psychiatric evaluation underwent polysomnography. Criteria for chronic fatigue syndrome (CFS) were met by 64% of patients and those for a current psychiatric disorder were met by 41%. Overall, 41% of patients had abnormal results for a multiple sleep latency test and 81% had at least one sleep disorder, most frequently sleep apnea (44%) and idiopathic hypersomnia (12%). In comparing patients who did and did not meet CFS criteria, no significant differences were found in individual sleep symptoms or sleep disorders. Likewise, symptoms and sleep disorders were unrelated to psychiatric diagnoses. In conclusion, chronically fatigued patients with suggestive symptoms may have potentially treatable coexisting sleep disorders that are not associated with meeting criteria for CFS or a current psychiatric disorder.
这项前瞻性队列研究调查了经过严格筛选的慢性疲劳患者的睡眠障碍患病率。基于筛查问卷中提示睡眠病理学的回答，来自一所大学慢性疲劳诊所的59名接受过医学和精神科评估的患者接受了多导睡眠图检查。64%的患者符合慢性疲劳综合征（CFS）标准，41%的患者符合当前精神障碍标准。总体而言，41%的患者多次睡眠潜伏期测试结果异常，81%的患者至少有一种睡眠障碍，最常见的是睡眠呼吸暂停（44%）和特发性嗜睡症（12%）。在比较符合和不符合CFS标准的患者时，未发现个体睡眠症状或睡眠障碍有显著差异。同样，症状和睡眠障碍与精神科诊断无关。总之，有提示性症状的慢性疲劳患者可能存在潜在可治疗的并存睡眠障碍，这些睡眠障碍与符合CFS标准或当前精神障碍无关。
