Littman A B, Fava M, Halperin P, Lamon-Fava S, Drews F R, Oleshansky M A, Bielenda C C, MacLaughlin R A
Department of Psychiatry, Massachusetts General Hospital, Boston 02114.
J Psychosom Res. 1993 May;37(4):345-54. doi: 10.1016/0022-3999(93)90136-4.
Stress reduction programs (SRPs) can reduce morbidity and mortality in patients with coronary artery disease (CAD). This study evaluated the effect of an SRP on metabolic and hormonal risk factors for CAD. Twenty army officers participating in an SRP, Group I, and a comparison group of seventeen SRP nonparticipants, Group C, volunteered to undergo measurement of dehydroepiandrosterone-sulfate (DHEA-S), cortisol, DHEA-S/cortisol ratio, testosterone, apolipoprotein-A1, apolipoprotein-B, triglycerides, cholesterol, fibrinogen, and leukocyte count both before and after the SRP period. No differences in the changes in biochemical risk factors for CAD were found between participant and nonparticipant except for DHEA-S. While Group C had a marked reduction in DHEA-S levels, Group I had a small increase. Previous studies indicate DHEA-S is inversely associated with extent of CAD and age-adjusted DHEA-S levels below 3.78 mumol/l confer an increased risk for CAD mortality. SRP participation appears to effect DHEA-S levels, possibly partially accounting for the benefits observed in SRPs among CAD patients.
减压方案（SRPs）可降低冠心病（CAD）患者的发病率和死亡率。本研究评估了一种减压方案对CAD代谢和激素风险因素的影响。20名参加减压方案的军官（第一组）和17名未参加减压方案的对照组人员（C组）自愿在减压方案实施前后接受硫酸脱氢表雄酮（DHEA-S）、皮质醇、DHEA-S/皮质醇比值、睾酮、载脂蛋白A1、载脂蛋白B、甘油三酯、胆固醇、纤维蛋白原和白细胞计数的测量。除了DHEA-S外，参加者和未参加者之间在CAD生化风险因素变化方面未发现差异。C组DHEA-S水平显著降低，而第一组略有升高。先前的研究表明，DHEA-S与CAD的严重程度呈负相关，年龄调整后的DHEA-S水平低于3.78μmol/L会增加CAD死亡风险。参加减压方案似乎会影响DHEA-S水平，这可能部分解释了在CAD患者的减压方案中观察到的益处。
