De Schryver-Kecskemeti K, Kyriakos M
Am J Pathol. 1977 Apr;87(1):33-46.
Tissue lesions similar to those in human myospherulosis were reproduced in experimental animals and studied by light and electron microscopy. The lesions were produced by the use of petrolatum-based antibiotic ointments. These ointments, which are marketed as nonsterile products, are similar to those used for hemostatic packing in otolaryngologic surgery. To date, use of these ointments has been reported to precede the finding of human paranasal sinus myospherulosis. The exact nature of the structures of myospherulosis remains unknown. The experimental evidence strongly suggests that they can be iatrogenically produced by the use of these nonsterile ointments.
在实验动物身上复制出了与人类肌球孢子菌病相似的组织病变，并通过光学显微镜和电子显微镜进行了研究。这些病变是通过使用凡士林基抗生素软膏产生的。这些作为非无菌产品销售的软膏，与用于耳鼻喉科手术止血填塞的软膏相似。迄今为止，据报道在发现人类鼻窦肌球孢子菌病之前就已使用了这些软膏。肌球孢子菌病结构的确切性质仍然未知。实验证据有力地表明，使用这些非无菌软膏可医源性地产生它们。
