Okugawa T, Rino Y, Okada K, Kobayashi O, Sairenji M, Motohashi H
Dept. of Surgery, Kanagawa Cancer Center Hospital.
Gan To Kagaku Ryoho. 1993 Jun;20(8):1059-62.
The patient was a 44-year-old male with gastric cancer accompanied by pancreatic invasion and metastasis to the periaortic lymph nodes. Combination chemotherapy with 5-FU, leucovorin (LCV) and CDDP (FLP therapy) was preoperatively given. Pancreaticoduodenectomy was carried out as absolutely noncurative resection. FLP therapy was continued postoperatively, and resulted in disappearance of the metastases in the periaortic lymph nodes on CT. As there were no findings of recurrence, the patient was regarded as being in complete response. In addition, the performance status improved from Grade 2 to Grade 0. Since the three-drug combination therapy induced only slight adverse reactions (Grades 1-2), it could be safely carried out at the outpatient department. Thus, combination therapy with 5-FU, LCV and CDDP is thought to be effective against gastric cancer.
该患者为一名44岁男性，患有胃癌，伴有胰腺侵犯及主动脉旁淋巴结转移。术前给予5-氟尿嘧啶、亚叶酸钙（LCV）和顺铂的联合化疗（FLP疗法）。实施了胰十二指肠切除术，为绝对非根治性切除。术后继续进行FLP疗法，CT检查显示主动脉旁淋巴结转移灶消失。由于未发现复发迹象，该患者被视为完全缓解。此外，其身体状况从2级改善至0级。由于三联药物联合疗法仅引起轻微不良反应（1-2级），故可在门诊安全进行。因此，5-氟尿嘧啶、LCV和顺铂的联合疗法被认为对胃癌有效。
