Iwao T, Toyonaga A, Ikegami M, Oho K, Sumino M, Sakaki M, Shigemori H, Harada H, Sasaki E, Tanikawa K
Second Department of Medicine, Kurume University School of Medicine, Japan.
Gastrointest Endosc. 1993 May-Jun;39(3):400-3. doi: 10.1016/s0016-5107(93)70114-5.
We measured regional gastric mucosal blood flow by laser Doppler flowmetry before and after control (n = 8) or cigarette smoking (n = 8) in healthy human beings. The control group showed no change in both antrum (from 1.15 +/- 0.32 to 1.20 +/- 0.39 V, NS) and corpus gastric mucosal blood flow (from 1.15 +/- 0.32 to 1.12 +/- 0.28 V, NS). In contrast, cigarette smoking caused a significant reduction in gastric mucosal blood flow in the antrum (from 1.08 +/- 0.31 to 0.71 +/- 0.22 V, p < 0.01) and in the corpus (from 0.99 +/- 0.26 to 0.66 +/- 0.24 V, p < 0.01). The magnitude of reduction in gastric mucosal blood flow was similar between the antrum and the corpus (-34% +/- 11% versus -33% +/- 15%, NS). We conclude that cigarette smoking induces a significant reduction in gastric mucosal blood flow and that no heterogeneous response occurs in regional gastric mucosa. In addition, the laser Doppler flowmeter appears to be a sensitive method to assess rapid change in gastric mucosal blood flow in human beings.
我们通过激光多普勒血流仪测量了健康人在对照（n = 8）或吸烟（n = 8）前后的局部胃黏膜血流量。对照组胃窦部（从1.15±0.32 V至1.20±0.39 V，无显著差异）和胃体部胃黏膜血流量（从1.15±0.32 V至1.12±0.28 V，无显著差异）均无变化。相比之下，吸烟导致胃窦部胃黏膜血流量显著降低（从1.08±0.31 V至0.71±0.22 V，p < 0.01）以及胃体部（从0.99±0.26 V至0.66±0.24 V，p < 0.01）。胃窦部和胃体部胃黏膜血流量降低的幅度相似（-34%±11%对-33%±15%，无显著差异）。我们得出结论，吸烟会导致胃黏膜血流量显著降低，且局部胃黏膜未出现异质性反应。此外，激光多普勒血流仪似乎是评估人体胃黏膜血流量快速变化的一种敏感方法。
