重度吸烟者的胃微循环与碳酸氢盐生成
Gastric microcirculation and bicarbonate production in heavy smokers.
作者信息
Guslandi M, Sorghi M, Pontikaki I, Tittobello A
机构信息
Gastroenterology Unit, S. Raffaele Hospital, University of Milan, Italy.
出版信息
Eur J Gastroenterol Hepatol. 1995 Oct;7(10):985-7. doi: 10.1097/00042737-199510000-00014.
OBJECTIVE
To determine the effect of chronic cigarette smoking on gastric mucosal blood flow and bicarbonate secretion.
METHODS
Three groups, each consisting of eight dyspeptic patients with normal endoscopic features, were studied: group A contained non-smokers, group B light smokers (< 10 cigarettes/day) and group C heavy smokers (> 10 cigarettes/day). Blood flow was measured in the gastric antrum by laser-Doppler flowmetry, and basal bicarbonate secretion was determined in fasting gastric juice by the method of Feldman.
RESULTS
Both mucosal blood flow and bicarbonate secretion were significantly reduced (P < 0.01) in group C.
CONCLUSION
In heavy smokers, gastric mucosal perfusion and alkali production are impaired. This can contribute to the noxious effects of smoking on the gastric mucosa. It remains to be determined whether these effects of smoking are causally related.
目的
确定长期吸烟对胃黏膜血流和碳酸氢盐分泌的影响。
方法
研究了三组，每组由八名内镜检查特征正常的消化不良患者组成：A组为不吸烟者，B组为轻度吸烟者（每天<10支香烟），C组为重度吸烟者（每天>10支香烟）。通过激光多普勒血流仪测量胃窦部的血流，并采用费尔德曼法测定空腹胃液中的基础碳酸氢盐分泌。
结果
C组的黏膜血流和碳酸氢盐分泌均显著降低（P<0.01）。
结论
在重度吸烟者中，胃黏膜灌注和碱生成受损。这可能导致吸烟对胃黏膜产生有害影响。吸烟的这些影响是否存在因果关系仍有待确定。
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