Odelin M F, Pozzetto B, Aymard M, Defayolle M, Jolly-Million J
Hôpital La Charité, CHU de Saint-Etienne, France.
Gerontology. 1993;39(2):109-16. doi: 10.1159/000213520.
During a winter epidemic of A/H1N1 influenza virus, we evaluated the protection conferred by vaccination of 285 residents of a nursing home. Fifteen of 204 members of the nursing staff were also vaccinated. Serological determinations were performed before and after vaccination using radial hemolysis (RH) and neuraminidase inhibition (NI) tests. In the outbreak period, only one influenza case was noted in the vaccinated elderly and none among the vaccinated nursing staff. On the other hand, 38 cases (20%) occurred in the unvaccinated hospital personnel. Twenty-one percent of the elderly people exhibited seroconversion to the vaccinal strain by RH and NI while 27 and 20% of the vaccinated nursing staff seroconverted by the same tests, respectively. Thus, the clinical protection conferred by influenza vaccination was excellent and much greater than expected from serological results.
在甲型H1N1流感病毒冬季流行期间，我们评估了一家养老院285名居民接种疫苗后的保护效果。204名护理人员中有15人也接种了疫苗。接种前后采用放射状溶血（RH）和神经氨酸酶抑制（NI）试验进行血清学检测。在疫情暴发期间，接种疫苗的老年人中仅发现1例流感病例，接种疫苗的护理人员中无病例发生。另一方面，38例（20%）发生在未接种疫苗的医院工作人员中。通过RH和NI检测，21%的老年人对疫苗株出现血清转化，而接种疫苗的护理人员中通过相同检测血清转化的比例分别为27%和20%。因此，流感疫苗接种所提供的临床保护效果极佳，远高于血清学结果预期。
