Guerin D, Hasan N, Keen C E
Department of Histopathology, Lewisham Hospital, London, UK.
Histopathology. 1993 Apr;22(4):367-71. doi: 10.1111/j.1365-2559.1993.tb00137.x.
Signet ring cell differentiation in adenocarcinoma of the prostate is uncommon. In a review of 200 cases of prostatic carcinoma, we identified five cases with this change, all in moderately to poorly differentiated prostatic carcinomas. The signet ring cells in prostatic carcinoma contain an intracytoplasmic lumen, shown on electronmicroscopy to be lined by microvilli. Transition stages were seen from solid to acinar to signet ring cells to mucinous variants. We believe that this change is part of the spectrum of appearances of prostatic carcinoma and should not be regarded as a subtype of specific significance.
前列腺腺癌中的印戒细胞分化并不常见。在对200例前列腺癌病例的回顾中，我们发现了5例有这种改变的病例，均为中分化至低分化前列腺癌。前列腺癌中的印戒细胞含有胞质内管腔，电镜显示其由微绒毛排列。可见从实性到腺泡状再到印戒细胞直至黏液性变体的过渡阶段。我们认为这种改变是前列腺癌表现谱的一部分，不应被视为具有特定意义的亚型。
