Chimura T, Hirayama T, Takase M
Department of Obstetrics and Gynecology, School of Medicine, Yamagata University.
Jpn J Antibiot. 1993 Apr;46(4):318-22.
The antimicrobial activity of cervical mucus is regarded as a local defense mechanism against ascending infections by the vaginal bacterial flora. In this study, the content of lactoferrin in cervical mucus of patients with chorioamnionitis (CAM) and its correlation with other indicators of infection were determined. The results obtained are summarized as follows: 1. The lactoferrin content in cervical mucous was higher in pregnant than in non-pregnant women. It was significantly lower in CAM(+) patients than in CAM(-) patients (P < 0.001) in preterm labor and was lower in preterm labor than in full-term control (P < 0.002). Elastase contents in cervical mucus of CAM(+) patients were significantly higher than full-term control levels (P < 0.001), and showed a negative correlation with lactoferrin contents. 2. With regard to other indicators of infection, CRP, ESR, and WBC were higher in CAM(+) patients and fibronectin was detected (> 50 ng/ml) in the cervical mucus of all CAM(+) patients.
宫颈黏液的抗菌活性被视为一种针对阴道细菌菌群上行感染的局部防御机制。在本研究中，测定了绒毛膜羊膜炎（CAM）患者宫颈黏液中乳铁蛋白的含量及其与其他感染指标的相关性。所得结果总结如下：1. 孕妇宫颈黏液中的乳铁蛋白含量高于非孕妇。在早产时，CAM（+）患者的乳铁蛋白含量显著低于CAM（-）患者（P<0.001），且早产时的含量低于足月对照组（P<0.002）。CAM（+）患者宫颈黏液中的弹性蛋白酶含量显著高于足月对照组水平（P<0.001），且与乳铁蛋白含量呈负相关。2. 关于其他感染指标，CAM（+）患者的CRP、ESR和WBC较高，且所有CAM（+）患者的宫颈黏液中均检测到纤维连接蛋白（>50 ng/ml）。
