Suzuki K, Inagaki T, Adachi S, Matsuura T, Yamamoto T
Department of Internal Medicine, Nagoya-shi Koseiin Geriatric Hospital, Japan.
Nihon Kyobu Shikkan Gakkai Zasshi. 1993 Apr;31(4):512-6.
We report a case of ceftazidime-induced pneumonitis. A 76-year-old man had been treated with cefotiam for acute pneumonia; however, he developed a high fever. On November 8, 1991, cefotiam was changed to ceftazidime and S-sulfonated human immunoglobulin. The patient showed good improvement. Four days after commencement of ceftazidime therapy, he developed chills, rigors, and high fever, with interstitial infiltrates in the right lung of his chest X-ray. On physical examination, small bubbling and crepitant rales were heard at the right lung. Once ceftazidime therapy was discontinued, he showed rapid resolution of symptoms and marked regression of the pulmonary infiltrates in the right lung of his chest X-ray. In view of the above, ceftazidime-induced pneumonitis was considered to be the diagnosis in this case. To our knowledge, there has been no previous case report of pulmonary hypersensitivity to ceftazidime. Clinicians should be alerted to the possibility of the occurrence of such a complication in patients being treated with ceftazidime.
我们报告1例头孢他啶诱发的肺炎。一名76岁男性因急性肺炎接受头孢替安治疗；然而，他出现了高热。1991年11月8日，将头孢替安换为头孢他啶及S-磺化人免疫球蛋白。患者病情明显改善。头孢他啶治疗开始4天后，他出现寒战、畏寒及高热，胸部X线显示右肺间质浸润。体格检查时，右肺可闻及少量细湿啰音和捻发音。一旦停用头孢他啶治疗，他的症状迅速缓解，胸部X线显示右肺的肺部浸润明显消退。鉴于上述情况，该病例被诊断为头孢他啶诱发的肺炎。据我们所知，此前尚无头孢他啶引起肺部超敏反应的病例报告。临床医生应警惕接受头孢他啶治疗的患者发生此类并发症的可能性。
