Hodgson T A, Shirlaw P J, Challacombe S J
Department of Oral Medicine and Pathology, United Medical School, Guy's Hospital, London, England.
Oral Surg Oral Med Oral Pathol. 1993 Jun;75(6):706-11. doi: 10.1016/0030-4220(93)90427-6.
Reactions to scratch and intradermal challenge with a variety of local anesthetics were examined in 90 patients and compared with 45 controls. The frequency of a positive scratch test was 13 of 90 in the patient group and 12 of 45 in the control group. Thus scratch testing did not appear to discriminate between test and control groups. Significantly greater numbers of patients (22 of 90) gave a positive intradermal response than controls (4 of 45) (chi-squared test p < 0.05). Nine patients showed reactions to more than one agent. The majority of reactions in both patients and controls were in atopic subjects (chi-squared test p < 0.05). In 87 of the 90 patients with suspected anaphylactoid reactions to local anesthetic agents, negative skin reactions to at least one of the agents allowed intrabuccal challenge and subsequent recommendation of an agent for future use. Skin testing, though not providing formal proof of allergy, provides a useful test to indicate local anesthetics that may be used for future procedures.
对90例患者进行了多种局部麻醉剂的划痕试验和皮内激发试验，并与45例对照者进行了比较。患者组划痕试验阳性的频率为90例中的13例，对照组为45例中的12例。因此，划痕试验似乎无法区分试验组和对照组。皮内反应阳性的患者数量（90例中的22例）显著多于对照组（45例中的4例）（卡方检验p<0.05）。9例患者对不止一种药物有反应。患者和对照组的大多数反应都出现在特应性受试者中（卡方检验p<0.05）。在90例疑似对局部麻醉剂有类过敏反应的患者中，87例对至少一种药物的皮肤反应为阴性，这使得可以进行口腔内激发试验，并随后推荐一种药物供未来使用。皮肤试验虽然不能提供过敏的正式证据，但却是一种有用的试验，可指示可用于未来手术的局部麻醉剂。
