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Influence of chronic intoxication with selenium on collagen and elastin content in tissues of rat.

作者信息

Kucharz E J, Olczyk K

机构信息

Fourth Department of Internal Medicine, Silesian School of Medicine, Sosnowiec, Poland.

出版信息

Toxicol Lett. 1993 Jun;68(3):295-9. doi: 10.1016/0378-4274(93)90020-x.

DOI:10.1016/0378-4274(93)90020-x
PMID:8516782
Abstract

Rats were intoxicated with sodium selenite (0.3 mg/kg body wt.) for 10 weeks. An increase in total collagen content in skin and a decrease in the lungs, liver and kidneys were observed. Enhanced serum and urine levels of collagen metabolites were found. Elastin content was shown to be increased in the lung, liver, heart muscle and kidney of selenium-intoxicated rats.

摘要

相似文献

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Both selenium deficiency and modest selenium supplementation lead to myocardial fibrosis in mice via effects on redox-methylation balance.
无论是硒缺乏还是适度的硒补充,都会通过对氧化还原-甲基化平衡的影响导致小鼠心肌纤维化。
Mol Nutr Food Res. 2012 Dec;56(12):1812-24. doi: 10.1002/mnfr.201200386. Epub 2012 Oct 24.
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Selenium toxicity but not deficient or super-nutritional selenium status vastly alters the transcriptome in rodents.硒毒性而非硒缺乏或超营养状态极大地改变了啮齿动物的转录组。
BMC Genomics. 2011 Jan 12;12:26. doi: 10.1186/1471-2164-12-26.