Jorgensen T G
Br J Surg. 1977 Apr;64(4):247-9. doi: 10.1002/bjs.1800640406.
In a retrospective study of 195 patients with a perforated peptic ulcer 18 per cent of the patients had taken aspirin, phenylbutazone or corticosteroids during the period before the perforation. In a controlled prospective trial, 18 of 22 patients (82 per cent) had taken drugs known to be potentially harmful to the stomach. Aspirin was the drug mainly used. Thirteen of 22 patients had taken the drugs within 12 hours of the perforation, usually because of symptoms not related to the gastro-intestinal tract. Drug consumption and perforation of pre-pyloric ulcers were most closely associated; the latter applies particularly to female patients, who either had only a short history of upper gastro-intestinal dyspepsia or were asymptomatic.
在一项对195例消化性溃疡穿孔患者的回顾性研究中，18%的患者在穿孔前的一段时间内服用过阿司匹林、保泰松或皮质类固醇。在一项对照前瞻性试验中，22例患者中有18例（82%）服用过已知对胃有潜在危害的药物。阿司匹林是主要使用的药物。22例患者中有13例在穿孔后12小时内服用过这些药物，通常是因为与胃肠道无关的症状。药物服用与幽门前溃疡穿孔的关联最为密切；后者尤其适用于女性患者，她们要么只有短暂的上消化道消化不良病史，要么没有症状。
