Ankola P A, Atakent Y S
Department of Pediatrics, Metropolitan Hospital Center, New York, NY 10029.
Am J Perinatol. 1993 May;10(3):229-32. doi: 10.1055/s-2007-994726.
A randomized controlled study was done to determine whether the addition of heparin, in very low concentration (0.25 U/ml), to fluids administered through an umbilical artery catheter (UAC) would affect the duration of catheter patency. UAC occlusion occurred in 2 of 15 patients in the heparin group and in 11 of 15 patients in the control group (p = 0.001). Using life-table analysis, the functional life span of UAC was estimated. On day 8, 100% of UACs in heparin group and 9% of UACs in control group were patent (p < 0.05). Coagulation profile remained unaltered after addition of heparin compared with that before the start of the therapy. There was no difference in the incidence of subependymal intraventricular hemorrhage between the two groups. It is concluded that heparin in such low concentration is effective in prolonging duration of UAC patency without causing adverse effects.
进行了一项随机对照研究，以确定在通过脐动脉导管（UAC）给药的液体中添加极低浓度（0.25 U/ml）的肝素是否会影响导管通畅的持续时间。肝素组15例患者中有2例发生UAC堵塞，对照组15例患者中有11例发生UAC堵塞（p = 0.001）。采用寿命表分析估计UAC的功能寿命。在第8天，肝素组100%的UAC通畅，对照组9%的UAC通畅（p < 0.05）。与治疗开始前相比，添加肝素后凝血指标未发生改变。两组之间室管膜下脑室内出血的发生率没有差异。得出的结论是，如此低浓度的肝素可有效延长UAC通畅的持续时间且不会引起不良反应。
