Reddy B S, Mastromarino A, Wynder E
Cancer. 1977 Apr;39(4 Suppl):1815-9. doi: 10.1002/1097-0142(197704)39:4+<1815::aid-cncr2820390812>3.0.co;2-w.
Epidemiological data demonstrate that colon cancer incidence is associated mainly with high dietary fat consumption. Studies in metabolic epidemiology indicate that high fat intake influences both the amount and type of bile acids and neutral sterols and intestinal microflora acting on these compounds which may contain tumorigenic activity for the colon. This is compatible with the results of studies comparing populations with high or low risk for the colon cancer and patients with colon cancer.
流行病学数据表明，结肠癌的发病率主要与高脂肪饮食的摄入有关。代谢流行病学研究表明，高脂肪摄入会影响胆汁酸、中性固醇的数量和类型以及作用于这些化合物的肠道微生物群，而这些化合物可能对结肠具有致癌活性。这与比较结肠癌高风险或低风险人群以及结肠癌患者的研究结果相符。
