Reddy B S, Weisburger J H, Wynder E L
J Nutr. 1975 Jul;105(7):878-84. doi: 10.1093/jn/105.7.878.
We investigated the effects of a high meat mixed Western diet and a nonmeat diet, representing the dietary pattern of high and low risk areas for colon cancer, respectively, on fecal microflora dn on bile acid and neutral sterol patterns in man. The total anaerobic microflora as well as the count of Bacteroides, Bifidobacterium, Peptococcus, and anaerobic Lactobacillus were significantly higher during the period of consumption of a high meat mixed Western diet comparted with the nonmeat-diet consumption period. The difference in total fecal bile acid excretion was not significant between the two dietary periods. Fecal excretion of microbially modified bile acids and neutral sterols was decreased when subjects eating a high meat diet transferred to a nonmeat diet. These results support the fact that diet plays a modifying role on the composition of intestinal microflora, bile acids, and neutral sterols.
我们研究了分别代表结肠癌高风险和低风险地区饮食模式的高肉混合西式饮食和非肉类饮食对人体粪便微生物群以及胆汁酸和中性固醇模式的影响。与非肉类饮食期相比，在食用高肉混合西式饮食期间，总厌氧微生物群以及拟杆菌、双歧杆菌、消化球菌和厌氧乳酸杆菌的数量显著更高。两个饮食期之间粪便总胆汁酸排泄的差异不显著。当食用高肉饮食的受试者转为非肉类饮食时，微生物修饰的胆汁酸和中性固醇的粪便排泄量减少。这些结果支持了饮食对肠道微生物群、胆汁酸和中性固醇的组成具有调节作用这一事实。
