Matsusue S, Nishimura S, Koizumi S, Nakamura T, Takeda H
Department of Abdominal Surgery, Tenri Hospital, Nara, Japan.
Surg Today. 1995;25(8):667-71. doi: 10.1007/BF00311480.
A prospective, randomized study was conducted to determine whether simultaneous infusion of lipid emulsion with an amino acid-dextrose-electrolyte solution would reduce the incidence of thrombophlebitis (TP) during postoperative peripheral parenteral nutrition (PPN). Thirty patients who had undergone gastric resection for adenocarcinoma were randomly divided into two groups according to whether they were infused with 10% lipid emulsion (group A) or 5% glucose solution (group B) simultaneously with the amino acid-glucose solutions. The total osmolarity of the infusion solutions in each group was 853 mOsm/l. The incidence of complications due to TP, namely, redness and/or edema beneath the cannula insertion site and/or pain, was investigated. There were no differences in the background characteristics of the patients in groups A and B, except regarding concurrent resection of other organs (P = 0.03). The incidence of edema in group A was significantly lower than in group B on postoperative days 2 and 4, although there was no difference in the incidence of redness and pain between the two groups. These findings suggest that the simultaneous infusion of lipid emulsion has a preventive effect against TP during postoperative PPN, and may be a practical means of providing PPN after gastrointestinal surgery.
进行了一项前瞻性随机研究，以确定在术后肠外营养（PPN）期间同时输注脂肪乳剂与氨基酸 - 葡萄糖 - 电解质溶液是否会降低血栓性静脉炎（TP）的发生率。30例因腺癌接受胃切除术的患者根据是否在输注氨基酸 - 葡萄糖溶液的同时输注10%脂肪乳剂（A组）或5%葡萄糖溶液（B组）被随机分为两组。每组输注溶液的总渗透压为853 mOsm/l。研究了由TP引起的并发症的发生率，即套管插入部位下方的发红和/或水肿和/或疼痛。A组和B组患者的背景特征除了其他器官的同期切除情况外（P = 0.03）没有差异。术后第2天和第4天，A组的水肿发生率显著低于B组，尽管两组之间发红和疼痛的发生率没有差异。这些发现表明，在术后PPN期间同时输注脂肪乳剂对TP有预防作用，并且可能是胃肠手术后提供PPN的一种实用方法。
