McKnight A, Clapham P R
Virology Laboratory, Chester Beatty Laboratories, Institute of Cancer Research, London, UK.
Trends Microbiol. 1995 Sep;3(9):356-61. doi: 10.1016/s0966-842x(00)88975-1.
HIV-1 cell tropisms are partly determined by the hypervariable loops V1/V2 and V3 in gp120, which also contain epitopes for neutralizing antibodies. Mutations conferring tropism changes can result in escape from neutralization and vice versa. We examine whether variant viruses that can colonize new cell types and simultaneously escape neutralizing antibodies have an enhanced advantage in vivo.
HIV-1的细胞嗜性部分由gp120中的高变环V1/V2和V3决定，这些高变环也包含中和抗体的表位。导致嗜性改变的突变可导致逃避中和作用，反之亦然。我们研究了能够定殖于新细胞类型并同时逃避中和抗体的变异病毒在体内是否具有增强的优势。
