Jadronová O, Kuzelová M, Seginko J, Svec P
Katedra farmakológie a toxikológie Farmaceutickej fakulty Univerzity Komenského, Bratislava.
Ceska Slov Farm. 1995 Oct;44(5):268-72.
Due to their molecular configuration, most free radicals are highly reactive and can cause cell injury. The present review deals with the role of oxygen-free radicals (OFR) in the pathogenesis of the heart disease and reperfusion injury. Cellular protection against deleterious effects of OFR is organized at multiple levels. Regulation of the antioxidant capacity includes not only the maintenance of adequate levels of antioxidants but the localisation of antioxidant compounds and enzymes as well. Synthetic antioxidants may mimic biological defence mechanisms.
由于其分子构型，大多数自由基具有高度反应性，可导致细胞损伤。本综述探讨了氧自由基（OFR）在心脏病发病机制和再灌注损伤中的作用。针对OFR有害影响的细胞保护在多个层面进行组织。对抗氧化能力的调节不仅包括维持足够水平的抗氧化剂，还包括抗氧化化合物和酶的定位。合成抗氧化剂可模拟生物防御机制。
