Rennert O M, Lawson D L, Shukla J B, Miale T D
Clin Chim Acta. 1977 Mar 15;75(3):365-9. doi: 10.1016/0009-8981(77)90354-0.
High-pressure chromatographic analysis of cerebrospinal fluid utilizing the o-phthalaldehyde-fluorescent detection system allows the reproducible detection of acid-soluble polyamines in this extracellular fluid compartment. Measurements made by this method in childhood acute lymphocytic leukemia appear to correlate with the remission-relapse status of the patient. The sensitivity of this analytic technique may allow much earlier detection of central nervous system disease. Studies are presently under way in our laboratories to define the usefulness of this technique to monitor successful chemotherapy of leukemia patients.
利用邻苯二甲醛-荧光检测系统对脑脊液进行高压色谱分析，可在这个细胞外液区室中对酸溶性多胺进行可重复检测。用这种方法对儿童急性淋巴细胞白血病进行的检测结果似乎与患者的缓解-复发状态相关。这种分析技术的敏感性可能使中枢神经系统疾病得到更早的检测。我们实验室目前正在进行研究，以确定该技术在监测白血病患者化疗成功方面的实用性。
