HIV阳性患者的脂肪酸与血浆抗氧化剂：与营养和免疫状态的相关性

Fatty acids and plasma antioxidants in HIV-positive patients: correlation with nutritional and immunological status.

作者信息

Constans J, Peuchant E, Pellegrin J L, Sergeant C, Hamon C, Dubourg L, Thomas M J, Simonoff M, Pellegrin I, Brossard G

机构信息

Service de Médecine Interne et Pathologie Vasculaire, Hôpital Saint-André, Bordeaux, France.

出版信息

Clin Biochem. 1995 Aug;28(4):421-6. doi: 10.1016/0009-9120(95)00017-4.

DOI:10.1016/0009-9120(95)00017-4

PMID:8521597

Abstract

OBJECTIVE

To investigate red blood cell (RBC) and plasma fatty acids (FA) in HIV-positive patients in relation to oxidative stress and nutritional or immunological status.

DESIGN AND METHODS

FA, plasma selenium, vitamins A and E were measured in 95 patients divided into four groups according to CD4 cells.

RESULTS

Poly- and di-unsaturated FA (PUFA, DUFA) decreased and saturated FA (SFA) increased in RBC in the patients below 400/mm3 and in plasma in the patients below 50/mm3. RBC SFA correlated to CD4 cells, PUFA to MDA. Unlike vitamin E, plasma vitamin A and selenium decreased in most groups. Plasma SFA and MUFA correlated negatively to selenium and PUFA and DUFA to vitamin E. No correlation was found between PUFA and nutritional markers.

CONCLUSION

FA seem to be modified during HIV infection by oxidative stress and disease evolution, but not by denutrition.

摘要

目的

研究HIV阳性患者的红细胞（RBC）和血浆脂肪酸（FA）与氧化应激以及营养或免疫状态的关系。

设计与方法

对95例患者进行FA、血浆硒、维生素A和维生素E的检测，这些患者根据CD4细胞计数分为四组。

结果

CD4细胞计数低于400/mm³的患者红细胞中的多不饱和脂肪酸（PUFA）和二不饱和脂肪酸（DUFA）减少，饱和脂肪酸（SFA）增加；CD4细胞计数低于50/mm³的患者血浆中的SFA增加。红细胞SFA与CD4细胞相关，PUFA与丙二醛（MDA）相关。与维生素E不同，大多数组的血浆维生素A和硒水平降低。血浆SFA和单不饱和脂肪酸（MUFA）与硒呈负相关，PUFA和DUFA与维生素E呈负相关。未发现PUFA与营养指标之间存在相关性。