Hengstermann Susanne, Valentini Luzia, Schaper Lennart, Buning Carsten, Koernicke Thomas, Maritschnegg Michaela, Buhner Sabine, Tillinger Wolfgang, Regano Nunzia, Guglielmi Francesco, Winklhofer-Roob Brigitte M, Lochs Herbert
Charité-Universitatsmedizin Berlin, Campus Mitte, Department of Gastroenterology, Charitéplatz 1, 10117 Berlin, Germany.
Clin Nutr. 2008 Aug;27(4):571-8. doi: 10.1016/j.clnu.2008.01.007. Epub 2008 Mar 7.
BACKGROUND & AIMS: Data regarding the nutritional status, antioxidant compounds and plasma fatty acid (FA) composition in inactive IBD are conflicting. We compared plasma levels of antioxidants and FA of patients with inactive IBD with active IBD and controls.
Plasma levels of vitamin C, vitamin E, carotenoids, saturated, monounsaturated and polyunsaturated FA, inflammatory markers and nutritional status were determined after an overnight fast in 132 patients with quiescent IBD (40.6+/-13.2 years, 87F/45M), 35 patients with active disease (37.9+/-12.1 years, 25F/10M) and 45 age- and BMI-matched healthy controls (38.1+/-10.5 years, 39F/6M). Results are expressed as mean+/-SD or median [25th percentile;75th percentile].
Body mass index (BMI) was normal in inactive (23.9+/-4.7 kg/m(2)), active IBD (22.7+/-4.2 kg/m(2)) and controls (22.3+/-1.9 kg/m(2)). Compared with controls patients with quiescent IBD showed significantly decreased plasma levels of carotenoids (1.85 [1.37;2.56] vs 1.39 [0.88;1.87] micromol/L) and vitamin C (62.3 [48.7;75.0] vs 51.0 [36.4;77.6] micromol/L), increased levels of saturated FA (3879 [3380;4420] vs 3410 [3142;3989] micromol/L) and monounsaturated FA (2578 [2258;3089] vs 2044 [1836;2434] micromol/L) and similar levels of vitamin E and polyunsaturated FA. Results in active disease were similar to inactive disease.
This study shows that antioxidant status and FA profile in a larger population of IBD patients are disturbed independently from disease activity and despite normal overall nutritional status.
关于非活动期炎症性肠病（IBD）患者的营养状况、抗氧化化合物及血浆脂肪酸（FA）组成的数据存在矛盾。我们比较了非活动期IBD患者与活动期IBD患者及对照组的血浆抗氧化剂和FA水平。
对132例静止期IBD患者（40.6±13.2岁，87例女性/45例男性）、35例活动期疾病患者（37.9±12.1岁，25例女性/10例男性）和45例年龄及体重指数（BMI）匹配的健康对照者（38.1±10.5岁，39例女性/6例男性）进行过夜禁食后，测定其血浆维生素C、维生素E、类胡萝卜素、饱和、单不饱和及多不饱和FA、炎症标志物和营养状况。结果以平均值±标准差或中位数[第25百分位数；第75百分位数]表示。
非活动期IBD患者（23.9±4.7kg/m²）、活动期IBD患者（22.7±4.2kg/m²）及对照组（22.3±1.9kg/m²）的体重指数（BMI）均正常。与对照组相比，静止期IBD患者的血浆类胡萝卜素水平显著降低（1.85[1.37；2.56]对1.39[0.88；1.87]μmol/L）和维生素C水平降低（62.3[48.7；75.0]对51.0[36.4；77.6]μmol/L），饱和FA水平升高（3879[3380；4420]对3410[3142；3989]μmol/L）和单不饱和FA水平升高（2578[2258；3089]对2044[1836；2434]μmol/L），而维生素E和多不饱和FA水平相似。活动期疾病的结果与非活动期疾病相似。
本研究表明，在更多IBD患者中，抗氧化状态和FA谱受到干扰，且与疾病活动无关，尽管总体营养状况正常。
