Druce J D, Jardine D, Locarnini S A, Birch C J
Victorian Infectious Diseases Reference Laboratory, Fairfield Hospital, Fairfield, Australia.
J Hosp Infect. 1995 Jul;30(3):167-80. doi: 10.1016/s0195-6701(95)90312-7.
Assays were developed to assess a variety of conditions and presentations of infectious HIV to potential inactivating sources. A range of commercially available disinfectants with active constituents including glutaraldehyde, chlorine, phenolics, alcohol, iodine and quaternary ammonium compounds was tested. In addition, u.v. light was investigated as a potential inactivating source. All products were assessed against cell-free HIV in culture medium and cell-associated HIV suspended in medium or whole human blood. All products completely inactivated cell-free HIV following a 1 min exposure. However, cell-associated HIV was more resilient, requiring exposure of 5 min or more for some disinfectants. The effectiveness of the disinfectants was further compromised in the presence of blood.
已开发出多种检测方法，以评估传染性HIV在各种条件下以及面对潜在灭活源时的表现形式。测试了一系列市售消毒剂，其活性成分包括戊二醛、氯、酚类、酒精、碘和季铵化合物。此外，还研究了紫外线作为潜在的灭活源。所有产品均针对培养基中的无细胞HIV以及悬浮在培养基或全血中的细胞相关HIV进行评估。所有产品在暴露1分钟后均能完全灭活无细胞HIV。然而，细胞相关HIV更具抗性，某些消毒剂需要暴露5分钟或更长时间。在有血液存在的情况下，消毒剂的有效性会进一步降低。
