Shah S M, Spalton D J
Cataract and Refractive Surgery Research Unit, St. Thomas' Hospital, London, England.
J Cataract Refract Surg. 1995 Jul;21(4):466-71. doi: 10.1016/s0886-3350(13)80542-1.
Previous cytopathological studies have demonstrated the presence of cellular deposits on the poly(methyl methacrylate) (PMMA) intraocular lens (IOL) surface. In this prospective study, IOL surface specular microscopy was used to document the natural history of these deposits in the first year following PMMA IOL implantation. Intraocular lens surface specular microscopy was performed 1, 3, 6, and 12 months after endocapsular cataract surgery in 27 otherwise normal eyes. Postoperatively, IOLs were assessed for the presence of inflammatory cells, with the number of cells graded from 0 (none) to 4 (many). Two inflammatory cell types were visualized: small and giant cells. Small cells were found on 81.5% of IOLs at 1 month, 73.1% at 3 months, and 30.4% at 12 months. Small cells were found in only small numbers (peak mean cell score of 1.26 +/- 0.94 at 1 month). Giant cells were found on 59.3% of lenses at 1 month, 73.1% at 3 months, and 39.1% at 12 months. The number of giant cells on each lens peaked at 3 months (mean cell score 2.0 +/- 1.55), when 50% of lenses achieved a giant cell score of 3 or 4. Inflammatory cell deposits are, therefore, a normal occurrence on the PMMA IOL surface for up to 1 year after surgery. This cellular response consists of two distinct processes: a small cell response, which peaks by 1 month, and a later giant cell response, which peaks at 3 months.
以往的细胞病理学研究已证实在聚甲基丙烯酸甲酯（PMMA）人工晶状体（IOL）表面存在细胞沉积物。在这项前瞻性研究中，IOL表面镜面显微镜被用于记录PMMA IOL植入后第一年这些沉积物的自然病程。对27只其他方面均正常的眼睛在囊内白内障手术后1、3、6和12个月进行IOL表面镜面显微镜检查。术后，评估IOL上炎症细胞的存在情况，细胞数量从0（无）到4（很多）分级。观察到两种炎症细胞类型：小细胞和巨细胞。小细胞在1个月时出现在81.5%的IOL上，3个月时为73.1%，12个月时为30.4%。小细胞数量很少（1个月时平均细胞评分峰值为1.26±0.94）。巨细胞在1个月时出现在59.3%的晶状体上，3个月时为73.1%，12个月时为39.1%。每个晶状体上巨细胞数量在3个月时达到峰值（平均细胞评分2.0±1.55），此时50%的晶状体巨细胞评分为3或4。因此，炎症细胞沉积物在手术后长达1年的时间里在PMMA IOL表面是正常现象。这种细胞反应由两个不同的过程组成：一个小细胞反应，在1个月时达到峰值，以及一个较晚的巨细胞反应，在3个月时达到峰值。
