呼肠孤病毒进入L细胞取决于液泡质子ATP酶的活性。
The entry of reovirus into L cells is dependent on vacuolar proton-ATPase activity.
作者信息
Martínez C G, Guinea R, Benavente J, Carrasco L
机构信息
Departamento de Bioquímica y Biología Molecular, Facultad de Farmacia, Universidad de Santiago de Compostela, La Coruña, Spain.
出版信息
J Virol. 1996 Jan;70(1):576-9. doi: 10.1128/JVI.70.1.576-579.1996.
Abstract
Inhibitors of vacuolar proton-ATPase activity (5 microM bafilomycin A1 or 50 nM concanamycin A) prevented infection by reovirus particles but not by infectious subviral particles (ISVPs). Neither compound affected virus attachment or internalization. However, both compounds potently blocked cleavage of the viral protein mu 1C. Finally, both reovirus particles and ISVPs efficiently translocated the toxin alpha-sarcin to the cytosol during virus entry. Bafilomycin A1 blocked translocation of alpha-sarcin by reovirus particles but not by ISVPs.
摘要
液泡质子 - ATP酶活性抑制剂（5微摩尔巴弗洛霉素A1或50纳摩尔抗霉素A）可阻止呼肠孤病毒颗粒感染，但不能阻止感染性子病毒颗粒（ISVP）感染。这两种化合物均不影响病毒的附着或内化。然而，这两种化合物均能有效阻断病毒蛋白μ1C的裂解。最后，在病毒进入过程中，呼肠孤病毒颗粒和ISVP均能有效地将毒素α - 肌动蛋白转运至细胞质中。巴弗洛霉素A1可阻止呼肠孤病毒颗粒转运α - 肌动蛋白，但不能阻止ISVP转运。
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