由α干扰素和γ干扰素诱导产生的抗病毒状态需要具有转录活性的Stat1蛋白。
The antiviral state induced by alpha interferon and gamma interferon requires transcriptionally active Stat1 protein.
作者信息
Horvath C M, Darnell J E
机构信息
Laboratory of Molecular Cell Biology, Rockefeller University, New York, New York 10021, USA.
出版信息
J Virol. 1996 Jan;70(1):647-50. doi: 10.1128/JVI.70.1.647-650.1996.
Abstract
Both of the latent transcription factors activated by alpha interferon or gamma interferon contain the Stat1 protein. The role of Stat1 in virus interference mediated by interferons was directly examined by using cultured cells expressing Stat1 protein and its variants. In the absence of Stat1, no antiviral state is established. Full complementation of the antiviral state requires full-length Stat1 which is phosphorylated on both tyrosine 701 and serine 727. The closely related signal transducer and activator of transcription protein Stat3 cannot substitute for the antiviral properties of Stat1.
摘要
由α干扰素或γ干扰素激活的两种潜在转录因子均含有Stat1蛋白。通过使用表达Stat1蛋白及其变体的培养细胞，直接研究了Stat1在干扰素介导的病毒干扰中的作用。在没有Stat1的情况下，无法建立抗病毒状态。抗病毒状态的完全互补需要在酪氨酸701和丝氨酸727上均被磷酸化的全长Stat1。密切相关的信号转导和转录激活蛋白Stat3不能替代Stat1的抗病毒特性。
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