Tomoda S, Kitanaka T, Ogita S, Hidaka A
Department of Obstetrics and Gynecology, Osaka City University Medical School, Japan.
J Obstet Gynaecol (Tokyo 1995). 1995 Jun;21(3):281-8. doi: 10.1111/j.1447-0756.1995.tb01011.x.
The purpose of this study is to clarify whether the taking of a calcium dietary supplement is able to prevent the development of pregnancy-induced hypertension (PIH) in Japanese people.
Forty-five nulliparous women (Ca-group) with various high-risk factors for PIH started to take a calcium supplement (1 g/day in the form of calcium salts) from the 12th gestational week (GW). Obstetrical outcome of Ca-group was compared to that of the nullipara (n = 453) who did not take a calcium supplement during pregnancy (Non-Ca Group) and that of the nullipara (n = 413) who did not develop PIH among Non-Ca group (normotensive group).
The incidence of PIH in the Ca-group was 2.2%, compared to 8.8% of Non-Ca group. The decrease in blood pressure after taking calcium during the first half of the pregnancy was much greater in Ca-group than in the normotensive group. The urinary excretion of sodium and calcium and serum free calcium at the 28th GW were much lower in a woman with PIH, despite of the taking of a calcium supplement, than in the normotensive calcium group. Also, the parathyroid hormone level at the 28th GW was higher in the calcium-taking woman with PIH than in the normotensive calcium group.
Our preliminary study suggests that among the possible effects of taking a calcium supplement are a decrease in blood pressure and the prevention of PIH in Japanese people, and that calcium metabolism might be related to the development of PIH. However, more study is needed before it will be possible to reach a final conclusion.
本研究旨在阐明服用钙膳食补充剂是否能够预防日本人妊娠期高血压（PIH）的发生。
45名有PIH各种高危因素的未生育女性（钙组）从妊娠第12周（GW）开始服用钙补充剂（钙盐形式，1克/天）。将钙组的产科结局与孕期未服用钙补充剂的未生育女性（n = 453）（非钙组）以及非钙组中未发生PIH的未生育女性（n = 413）（血压正常组）的产科结局进行比较。
钙组PIH的发生率为2.2%，而非钙组为8.8%。妊娠前半期服用钙后，钙组血压的下降幅度比血压正常组大得多。尽管服用了钙补充剂，但PIH女性在第28周GW时的尿钠、尿钙排泄量和血清游离钙水平均低于血压正常的钙组。此外，服用钙的PIH女性在第28周GW时的甲状旁腺激素水平高于血压正常的钙组。
我们的初步研究表明，服用钙补充剂的可能作用包括降低血压以及预防日本人患PIH，并且钙代谢可能与PIH的发生有关。然而，在得出最终结论之前还需要更多的研究。
