Seow W K, Needleman H L, Holm I A
University of Queensland Dental School, Australia.
Pediatr Dent. 1995 Sep-Oct;17(5):346-50.
Familial or X-linked hypophosphatemic rickets (XLHR) is the most common type of rickets in developed countries today. While the dental manifestations of rickets are well reported, there is little information regarding its relationship to dental development and other dental anomalies. This investigation studied the rate of dental development and associated dental anomalies in 19 XLHR subjects compared with 38 race-, age-, and sex-matched control children. The results showed that in both XLHR and control children, no significant differences existed in dental age compared with the respective chronological age, indicating that rickets did not affect the rate of dental development. Longitudinal growth curves of seven XLHR and matched control children substantiated that relationships of dental to chronological ages were comparable in both groups. Male XLHR subjects showed significantly increased tendency for dental taurodontism with mean Crown-Body (CB):Root (R) ratio of 1.1 compared with 1.0 in females and 0.8 in controls (P < 0.02). Male XLHR children also showed significantly increased prevalence (50%) of ectopic permanent canines compared with control children (8%, P < 0.01).
家族性或X连锁低磷性佝偻病（XLHR）是当今发达国家最常见的佝偻病类型。虽然佝偻病的牙齿表现已有充分报道，但关于其与牙齿发育及其他牙齿异常关系的信息却很少。本研究比较了19名XLHR受试者与38名种族、年龄和性别匹配的对照儿童的牙齿发育速率及相关牙齿异常情况。结果显示，在XLHR儿童和对照儿童中，牙齿年龄与各自的实际年龄相比均无显著差异，这表明佝偻病不影响牙齿发育速率。7名XLHR儿童和匹配对照儿童的纵向生长曲线证实，两组中牙齿年龄与实际年龄的关系具有可比性。男性XLHR受试者牙齿牛牙症的发生率显著增加，平均冠体（CB）与根（R）的比例为1.1，而女性为1.0，对照儿童为0.8（P<0.02）。与对照儿童（8%，P<0.01）相比，男性XLHR儿童异位恒牙尖牙的患病率也显著增加（50%）。
