Kat P W, Alexander K A, Smith J S, Munson L
Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis 95616, USA.
Proc Biol Sci. 1995 Nov 22;262(1364):229-33. doi: 10.1098/rspb.1995.0200.
Three packs of African wild dogs (Lycaon pictus) ranging to the north of the Masai Mara National Reserve in southwestern Kenya were monitored from 1988 to 1990. During a six week period (August 2-September 14, 1989), 21 of 23 members of one of these packs died. Histological examination of two brain samples revealed eosinophilic intracytoplasmic inclusions (Negri bodies), supporting a diagnosis of rabies viral encephalitis. An additional brain sample tested positive for rabies with a fluorescent antibody test. Nucleotide sequence of the rabies viral N and G genes from isolates of four African wild dogs (including an individual from Tanzania) indicated that infection was with a viral variant common among domestic dogs in Kenya and Tanzania. A hypothesis linking African wild dog rabies deaths to researcher handling is evaluated and considered implausible.
1988年至1990年期间，对肯尼亚西南部马赛马拉国家保护区以北活动的三群非洲野犬（非洲野犬属）进行了监测。在1989年8月2日至9月14日的六周时间里，其中一群23只野犬中有21只死亡。对两份脑部样本进行组织学检查，发现嗜酸性胞质内包涵体（内基小体），支持狂犬病病毒性脑炎的诊断。另一份脑部样本通过荧光抗体检测呈狂犬病阳性。对来自四只非洲野犬（包括一只来自坦桑尼亚的个体）的狂犬病病毒分离株的N和G基因进行核苷酸序列分析，结果表明感染的是在肯尼亚和坦桑尼亚家犬中常见的病毒变种。一种将非洲野犬狂犬病死亡与研究人员操作联系起来的假设经过评估，被认为不太可能成立。
