Kat P W, Alexander K A, Smith J S, Richardson J D, Munson L
Department of Veterinary Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis 95616, USA.
J Vet Diagn Invest. 1996 Oct;8(4):420-6. doi: 10.1177/104063879600800403.
A pack of African wild dogs (Lycaon pictus) ranging to the north of the Masai Mara National Reserve in southwestern Kenya was monitored from 1988 to 1989. During a 6-week period (August 1-September 13, 1989), 21 of 23 members of this pack died. Seven carcasses were retrieved, of which 4 were suitable for necropsy and histopathologic examination. Gross findings varied among individuals and included multiple bite wounds, synovitis, lymphadenopathy, submandibular, cervical, and vocal cord edema, blood in bronchi, bronchioles, stomach, and intestine, and interioventral lung lobe consolidation. Histologic examination of 2 available brain samples revealed nonsuppurative encephalitis with eosinophilic intracytoplasmic inclusions (Negri bodies). An additional brain sample tested positive for rabies via a fluorescent antibody test. Other histologic features included severe suppurative bronchopneumonia, myocarditis, and lymphoid depletion of the lymph nodes, tonsils, and spleen. A 304-base pair (bp) nucleotide sequence from the N gene and a 310-bp sequence from the G gene from rabies isolates of 4 wild dogs indicated that infection was with a rabies variant common among domestic dogs in Kenya and Tanzania.
1988年至1989年，对一群活动于肯尼亚西南部马赛马拉国家保护区北部的非洲野犬（非洲野犬属）进行了监测。在1989年8月1日至9月13日这6周时间里，这群野犬中的23只成员有21只死亡。找回了7具尸体，其中4具适合进行尸检和组织病理学检查。大体检查结果因个体而异，包括多处咬伤、滑膜炎、淋巴结病、下颌下、颈部和声带水肿、支气管、细支气管、胃和肠道内有血液，以及腹侧肺叶实变。对2份可用的脑样本进行组织学检查，发现非化脓性脑炎伴有嗜酸性胞浆内包涵体（内基小体）。另一份脑样本通过荧光抗体试验检测出狂犬病呈阳性。其他组织学特征包括严重的化脓性支气管肺炎、心肌炎以及淋巴结、扁桃体和脾脏的淋巴细胞耗竭。来自4只野犬狂犬病分离株的N基因304个碱基对（bp）的核苷酸序列和G基因310个碱基对的序列表明，感染的是肯尼亚和坦桑尼亚家犬中常见的一种狂犬病变种。
