West H J
Department of Veterinary Clinical Science and Animal Husbandry, University of Liverpool, Leahurst, Neston, South Wirral.
Res Vet Sci. 1995 Sep;59(2):176-9. doi: 10.1016/0034-5288(95)90056-x.
The kinetics of indocyanine green removal from the blood after a single intravenous injection were measured in sheep and compared with those of a single dose of bromosulphthalein given to the same animals 48 hours later. A single dose of 1.5 mg kg-1 of indocyanine green (ICG) was cleared in a double exponential manner. The hepatic uptake of ICG was not significantly different from that of bromosulphthalein (BSP) but its rate of excretion in bile was significantly lower (P < 0.05) and its rate of plasma reflux significantly higher (P < 0.05). The plasma distribution volumes of the two compounds were similar but the mean (SD) plasma clearance of ICG (435 [228.6] ml min-1) was significantly lower than that of BSP (626 [291.9] ml min-1) (P < 0.05). The retention of ICG 30 minutes after the injection was significantly higher than that of BSP (P < 0.01).
单次静脉注射后，在绵羊身上测量了吲哚菁绿从血液中清除的动力学，并与48小时后给同一批动物注射的单剂量酚四溴酞磺酸钠的动力学进行了比较。1.5 mg/kg的单剂量吲哚菁绿（ICG）以双指数方式清除。ICG的肝脏摄取与酚四溴酞磺酸钠（BSP）没有显著差异，但其胆汁排泄率显著更低（P < 0.05），血浆反流率显著更高（P < 0.05）。两种化合物的血浆分布容积相似，但ICG的平均（标准差）血浆清除率（435 [228.6] ml/min）显著低于BSP（626 [291.9] ml/min）（P < 0.05）。注射后30分钟时ICG的潴留显著高于BSP（P < 0.01）。
