Gérard Y, Couppié P, del Giudice P, Mille H, Cuchet T, Sainte-Marie D, Pradinaud R
Service de dermato-vénéréo-léprologie, centre hospitalier, Cayenne, Guyane, France.
Rev Med Interne. 1995;16(10):767-70. doi: 10.1016/0248-8663(96)80786-7.
The authors report two cases of disseminated histoplasmosis occurring in HIV-infected patients living in French Guiana. The first case was an acute disseminated histoplasmosis with a rapid fatal evolution. The second case was diagnosed on a mucosal localisation, and improved under itraconazole therapy. These two cases show the diversity of the clinical course of this opportunistic infection. The authors focus on the difficulty of the diagnosis and the need for direct microscopic examination to identify histoplasma and to enable a swift therapeutic intervention.
作者报告了两例发生在法属圭亚那的HIV感染患者中的播散性组织胞浆菌病病例。第一例为急性播散性组织胞浆菌病，病情迅速发展并致命。第二例在黏膜部位确诊，接受伊曲康唑治疗后病情好转。这两例病例显示了这种机会性感染临床病程的多样性。作者着重指出了诊断的困难以及直接显微镜检查对于识别组织胞浆菌和实现快速治疗干预的必要性。
